研究業績

原著論文(英文)  2008年〜2011年


(1) Inoue T, Kobayashi K, Inoguchi T, Sonoda N, Fujii M, Maeda Y, Fujimura Y, Miura D, Hirano K, Takayanagi R.
Reduced expression of adipose triglyceride lipase enhanced tumor necrosis factor-α-induced intracellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase C-dependent activation of nuclear factor-κB.
J Biol Chem. In press.
(2) Wang KY, Tanimoto A, Guo X, Yamada S, Shimajiri S, Murata Y, Ding Y, Tsutsui M, Kato S, Watanabe T, Ohtsu H, Hirano K, Kohno K, Sasaguri Y.
Histamin deficiency decreased atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol levels. Arterioscler Thromb Vasc Biol. 31: 800-807, 2011.
(3) Nagasaka H, Yorifuji T, Okano Y, Tsukahara H, Yanai H, Hirano K, Hui SP, Hirayama S, Chiba H, Miida T.
CD36 deficiency predisposing young children to hypoglycemia. Metabolism. 60: 881-7, 2011.
(4) Wang KY, Tanimoto A, Yamada S, Guo X, Ding Y, Watanabe T, Kohno K, Hirano K, Tsukuda H, Sasaguri Y.
Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalocoholic steatohepatitis in mice. Am J Pathol. 177: 713-23, 2010.
(5) Nagasaka H, Okano Y, Aizawa M, Miida T, Yorifuji T, Tajima G, Sakura N, Takatani T, Sanayama Y, Sugamoto K, Mayumi M, Kobayashi K, Hirano K, Takayanagi M, Tsukahara T.
Altered metabolisms of mediators controlling vascular function and enhanced oxidative stress in asymptomatic children with congenital portosystemic venous shunt. Metabolism. 59: 107-113, 2010.
(6) Hirano K.
A novel clinical entity: triglyceride deposit cardiomyovasculopathy – Implications and perspectives from “Obesity of the Heart”. J Atheroscler Thromb. 16: 702-205, 2009.
(7) Nagasaka H, Okano Y, Tsukahara H, Shigematsu Y, Momoi T, Yorifuji J, Miida T, Ohura T, Kobayashi K, Saheki T, Hirano K, Takayanagi M, Yorifuji T.
Sustained hypercitrullinemia, hypercholesterolemia and augmented oxidative stress in Japanese children with aspartate/glutamate carrier isoform 2-citrin-deficiency even during the silent period. Mol Genet Metab. 97: 21-26, 2009.
(8) Nagasaka H, Yorifuji T, Hirano K, Ota A, Nakagawa-Toyama Y, Takatani T, Tsukahara H, Kobayashi K, Takayanagi M, Inomata Y, Uemoto S, Miida T.
Effects of bezafibrate on dyslipidemia with cholestasis in children with familial intrahaptic cholestasis-1 deficiency manifesting progressive familial intrahepatic cholestasis. Metabolism. 58; 48-54, 2009.
(9) Koseki M, Matsuyama A, Nakatani K, Inagaki M, Nakaoka H, Kawase R, Yuasa-Kawase M, Tsubakio-Yamamoto K, Masuda D, Sandoval JC, Ohama T, Nakagawa-Toyama Y, Matsuura F, Nishida M, Ishigami M, Hirano K, Sakane N, Kumon Y, Suehiro T, Nakamura T, Shimomura I, Yamashita S.
Impaired insulin secretion in four Tangier disease patients with ABCA1 mutations. J Atheroscler Thromb. 16: 292-296, 2009.
(10) Nagasaka H, Yorifuji T, Momoi T, Yorifuji J, Hirano K, Ota A, Takatani T, Tsukahara H, Takayanagi M, Kobayashi K, Chiba H, Sato Y, Miida T.
Lipoprotein profiles in children with two common cholesteryl ester transfer protein gene mutations. D442G and I14A, during the first year of life. Clin Chim Acta. 406: 52-6, 2009.
(11) Hirano K, Ikeda Y, Zaima N, Sakata Y, Matsumiya G.
Triglyceride deposit cardiomyovasculopathy. N Engl J Med. 359; 2396-2398, 2008.
(12) Masuda D, Hirano K, Oku H, Sandoval JC, Kawase R, Yuasa-Kawase M, Yamashita Y, Takada M, Tsubakio-Yamamoto K, Tochino Y, Koseki M, Matsuura F, Nishida M, Kawamoto T, Ishigami M, Hori M, Shimomura I, Yamashita S.
Chylomicron remnant are increased in the postprandial state in CD36 deficiency. J Lipid Res. 50: 999-1011, 2009.
(13) Sogo T, Nagasaka H, Komatsu H, Inui A, Miida T, Francalanci P, Hirano K, Kitamura H, Fujisawa T.
A young Japanese boy with fibrinogen storage disease caused by Aguadilla mutation presenting with hypobeta-lipoproteinemia together with considerable liver disease. J Pediat Gastro Nutr. 49: 133-136, 2009.
(14) Nagasaka H, Miida T, Hirano K, Ota A, Maruyama K, Yorifuji T, Kobayashi K, Takatani T, Tsukahara H, Hui SP, Takatani T, Takayanagi M, Chiba H.
Fluctuation of lipoprotein metabolism linked with bile acid-activated liver nuclear receptors in Alagille syndrome. Atherosclerosis. 198; 434-440, 2008.
(15) Nagasaka H, Miida T, Hirano K, Ota A, Yorifuji T, Takatani T, Tsukahara H, Takayanagi M, Hui SP, Kobayashi K, Chiba H.
Reduced apolipoprotein E-rich high density lipoprotein level at birth is restored to the normal range in patients with familial hypercholesterolemia in the first year of life. J Clin Endocrin Metab. 93: 779-783, 2008.



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