研究業績

原著論文(英文)  2007年以前(主要なもの)


(1) Matsuura F, Hirano K, Ikegami C, Sandoval JC, Oku H, Yuasa-Kawase M, Tsubakio-Yamamoto K, Koseki M, Masuda D, Tsujii K, Ishigami M, Nishida M, Shimomura I, Hori M, Yamashita S.
Senescent phenotype of skin fibroblasts from patients with Tangier disease. Biochem Biophys Res Commun. 357: 493-498, 2007.
(2) Nagasaka H, Chiba H, Hui SP, Hajime T, Miida T, Takayanagi M, Yorifuji T, Hasegawa M, Ota A, Hirano K, Kikuchi H, Tsukahara H, Koyayashi K.
Depletion of high-density lipoproteins and appearance of triglyceride-rich low-density lipoproteins in a Japanese patient with FIC1 deficiency manifesting benign recurrent intrahepatic cholestasis. J Pediatr Gastro Nutr. 45(1): 96-105, 2007.
(3) Nagasaka H, Hirano K, Ohtake A, Miida T, Takatani T, Maruyama K, Yorifuji T, Kobayashi K, Kanazawa M, Ogawa A, Takayanagi M.
Improvement of hypertriglyceridemia and hyperlacticemia in Japanese children with glycogen storage disease type Ia by medium chain triglyceride milk. Eur J Pediatr. 166(10): 1009-1016, 2007.
(4) Koseki M, Hirano K, Masuda D, Ikegami C, Tanaka M, Ota A, Sandoval JC, Nakagawa-Toyama, Sata SB, Kobayashi T, Shimada Y, Ohno-Iwashaita Y, Matsuura F, Shimomura I, Yamashita S.
Increased lipid raft and accelerated TNF alpha release from ABCA1-deficient macrophages. J Lipid Res. 48: 299-306, 2007.
(5) ○Hirano K, Ikegami C, Tsujii K, Zhang Z, Nakagawa-Toyama Y, Koseki M, Masuda D, Shimomura I, Ueda Y. Maruyama T, Yamashita S.
Probucol enhances the expression of scavenger receptor class B type I possibly through species-specific fashion. Arterioscler Thromb Vasc Biol. 25: 2422-2427, 2005.
(6) Matsuura F, Hirano K (Equal contribution), Nakamura T, Yoshizumi T, Yamashita S.
A novel familial massive xanthomatosis with decreased cholesterol efflux. Metabolism. 54: 1095-1101, 2005.
(7) Zhang Z, Hirano K, Tsukamoto K, Ikegami C, Koseki M, Saijo K, Ohno T, Sakai N, Hiraoka H, Shimomura I, Yamashita S.
Defective cholesterol efflux in Werner syndrome fibroblasts and its phenotypic correction by Cdc42, a RhoGTPase. Exp Geront. 40: 286-294, 2005. (Corresponding author).
(8) Kuwasako T, Hirano K, Sakai N, Ishigami M, Hiraoka H, Janabi MY, Yamauchi-Takihara K, Yamashita S, Matsuzawa Y.
Lipoprotein abnormalities in human genetic CD36 deficiency associated with insulin resistance and abnormal fatty acid metabolism. Diabetes Care. 26: 1647-1648, 2003 (Corresponding author).
(9) Tsukamoto K, Hirano K, Yamashita S, Sakai N, Ikegami C, Zhang Z, Matsuura F, Hiraoka H, Matsuyama A, Ishigami M, Matsuzawa Y.
Retarded Intracellular Lipid Transport Associated with Reduced Expression of a Member of RhoGTPases, Cdc42, in Human Aged Skin Fibroblasts. - A Possible Function of Cdc42 to Mediate Intracellular Lipid Transport - Arterioscler Thromb Vasc Biol. 22:1899-1904, 2002 (Corresponding author).
(10) Ohama T, Hirano K (Equal contribution), Zhang Z, Aoki R, Nakagawa-Toyama Y, Tsukamoto K, Ikegami C, Matsuyama A, Ishigami M, Naohiko S, Hiraoka H, Ueda K, Yamashita S, Matsuzawa Y.
Dominant expression of ATP-binding cassette transporter-1 (ABCA1) on basolateral surface of Caco-2 cells stimulated by LXR/RXR ligands. Biochem Biophys Res Commun. 296: 625-630, 2002 (Corresponding author).
(11) Nishida Y, Hirano K, Tsukamoto K, Nagano M, Roomp K, Ishihara M, Sakane N, Zhang Z, Tsujii K, Matsuyama A, Ohama T, Matsuura F, Ishigami M, Sakai N, Hiraoka H, Hattori H, Wellington C, Yoshida Y, Misugi S, Hayden MR, Egashira T, Yamashita S, Matsuzawa Y.
Expression of functional analyses of novel mutations in ATP-binding cassette transporter-1 in Japanese patients with high density lipoprotein deficiency. Biochem Biophys Res Commun. 290: 713-721, 2002 (Corresponding author).
(12) Tsukamoto K, Hirano K, Tsujii K, Ikegami C, Zhang Z, Matsuura F, Yamashita S, Matsuzawa.
ATP-binding Cassette Transporter-1 (ABCA1) Induces Rearrangement of Actin Cytoskeletons through Possible Interaction between ABCA1 and Cdc42. Biochem Biophys Res Commun. 287: 757-765, 2001 (Corresponding author).
(13) ○Miyaoka K, Kuwasako T, Hirano K, Yamashita S, Matsuzawa Y.
CD36 deficiency is associated with insulin resistance. Lancet. 357; 686-687, 2001. (Corresponding author).
(14) ○Hirano K, Matsuura F, Zhang Z, Tsukamoto K, Matsuyama A, Takaishi K, Komuro R, Suehiro T, Yamashita S, Takai Y, Matsuzawa Y.
Decreased expression of a member of RhoGTPases family, Cdc42Hs, in cells from Tangier disease. – The G protein may play a role in cholesterol efflux from the cells-. FEBS letter. 484: 275-279, 2000.
(15) Matsumoto K, Hirano K, Nozaki S, Takamoto A, Nishida M, Nakagawa-Toyama Y, Janabi MY, Ohya T, Yamashita S, Matsuzawa Y.
Expression of Macrophage Scavenger Receptor, CD36, in Cultured Human Aortic Smooth Muscle Cells, in Association with the Expression of Peroxisome Proliferator Activator Receptor- -Gain of M-like Phenotype In Vitro and Its Implication in Atherogenesis- Arterioscler Thromb Vasc Biol. 20: 1027-1032, 2000. (Corresponding author).
(16) Komuro R, Yamashita S, Sumitsuji S, Hirano K, Maruyama T, Nishida M, Matsuura F, Matsuyama A, Sugimoto T, Ouch N, Sakai S, Nakamura T, Funahashi T, Matsuzawa Y.
Tangier Disease with Continuously Massive and Longitudinal Diffuse Calcification in the Coronary Arteries -Demonstration by the Sagittal Images of Intravascular Ultrasoundgraphy- Circulation. 101: 2446-2448, 2000. (Corresponding author).
(17) ○Hirano K, Yamashita S, Nakagawa N, Ohya T, Matsuyama A, Okamoto Y, Matsumoto K, Matsuura F, Sakai N, Miyagawa J, Matsuzawa Y.
Expression of human scavenger receptor class B type I in cultured human monocyte-derived macrophages and in human atherosclerotic lesions. Circ Res. 85: 108-116, 1999.
(18) Lee RM, Hirano K, Anant S, Baunoch D, Davidson NO.
An Alternatively Spliced Form of Apobec-1 Messenger RNA Is Overexpressed in Human Colon Cancer. Gastroenterology. 115: 1096-1103, 1998.
(19) ○Hirano K, Yamashita S, Nakajima N, Yoshida Y, Arai T, Sakai N, Ishigami M, Takemura K, Matsuzawa Y.
Genetic cholesteryl ester transfer protein deficiency is extremely frequent in Omagari area of Japan. - Marked hyperalphalipoproteinemia caused by cholesteryl ester transfer protein gene mutation is not a longevity syndrome. Arterioscler Thromb Vasc Biol. 17; 1053-1059, 1997.
(20) Hirano K, Min J, Funahashi T, Davidson NO.
Characterization of the human apobec-1 gene: Expression in gastrointestinal tissue determined by alternative splicing with production of a novel truncated peptide. J Lipid Res. 38: 847-859, 1997.
(21) Hirano K, Min J, Funahashi T, Davidson NO.
Cloning and characterization of the rat apobec-1 gene. A comparative analysis of the gene structure and promoter usage in rat and mouse. J Lipid Res. 38: 1103-1119, 1997.
(22) Burant CF, Sreenan S, Hirano K, Chang Tzu-Ann, Lohmiller J, Lukens J, Davidson NO, Ross S, Graves R.
Troglitazone action is independent of adipose tissue. J Clin Invest. 100: 2900-2908, 1997.
(23)○Hirano K, Young SG, Farese RV, Ng J, Sande E, Warburton C, Powell-Braxton LM, Davidson NO.
Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem. 271: 9887-9890, 1996.
(24)Hirano K, Yamashita S, Sakai N, Nozaki S, Arai T, Takemura K, Matsuzawa Y.
Molecular basis and atherogenicity in cholesteryl ester transfer protein deficiency. Ann NY Acad Sci. 748: 599-602, 1995.
(25)○Hirano K, Yamashita S, Kuga Y, Sakai N, Nozaki S, Kihara S, Arai T, Yanagi K, Takami S, Menju M, Ishigami M, Yoshida Y, Kameda-Takemura K, Hayashi K, Matsuzawa Y.
Atherosclerotic disease in marked hyperalphalipoproteinemia. - Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase. Arterioscler Thromb Vasc Biol. 15: 1849-1856, 1995.
(26) Hirano K, Yamashita S, Funahashi T, Sakai N, Menju M, Ishigami M, Hiraoka H, Takemura K, Tokunaga K, Hoshino H, Kumasaka K, Kawano K, Matsuzawa Y.
Frequency of intron 14 splicing defect of cholesterly ester transfer protein gene in Japansese general population. Relation between the mutation and hyperalphalipoproteinemia. Atherosclerosis. 100: 85-90, 1993.
(27)Nozaki S, Matsuzawa Y, Hirano K, Sakai N, Kubo M, Tarui S.
Effects of purified eicosapentaenoic acid ethyl ester on plasma lipoproteins in primary hypercholesterolemia. Internat J Vit Res. 62: 256-260, 1992.
(28)Hirano K, Matsuzawa Y, Sakai N, Hiraoka H, Nozaki S, Funahashi T, Yamashita S, Kubo M, Tarui S.
Polydisperse low density lipoproteins in hyperalphalipoproteinemic chronic alcohol drinkers in association with marked reduction of cholesteryl ester transfer activity. Metabolism. 41: 1313-1318, 1992.
(29)Hirano K, Yamashita S, Sakai N, Ueyama Y, Funahashi T, Matsuzawa Y.
Low density lipoproteins in hyperalphalipoproteinemic chronic alcohol drinkers have reduced affinity for low density lipoprotein receptor. Clin Biochem 25: 357-363, 1992.




研究業績メニューへ